Pyroluria

Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. Hemoglobin is the protein that holds iron in the red blood cell. Individuals with Pyroluria produce too much of a byproduct of hemoglobin synthesis called “kryptopyrrole”(KP) or “hemepyrrole.” 

Kryptopyrrole binds to zinc and pyridoxine(vitamin B6) and makes them unavailable for their crucial roles as co-factors in enzymes and metabolism.  When these essential nutrients are bound to kryptopyrroles they are removed from the bloodstream and excreted into the urine as pyrroles. 

Dr. Klinghart states that incidence of Pyroluria in his patients is 80% or higher.

Symptoms of Pyroluria are:

  • Schizophrenia
  • ADHD
  • Autism;
  • Bipolar disorder;
  • Anxiety (including panic attacks)
  • Depression
  • Alcoholism
  • Poor dream recall
  • Low tolerance for stress
  • Antisocial behavior
  • Behavioral problems (especially in children and teenagers) such as oppositional/defiant disorder
  • Emotional instability, explosive temper
  • Frequent joint pain
  • Frequent infections
  • Poor appetite, especially in the morning
  • Low tolerance for protein - tend to favor vegetarian diets
  • Pale complexion, inability to tan
  • White flecks on the fingernails
  • Nausea, motion sickness
  • Hypoglycemia
  • Allergies
  • Fatigue
  • Crowded teeth and poor quality of the tooth enamel
  • Retracted gums
  • Sweet or fruity-smelling breath and sweat

Great Plains Lab has a urine test for Pyroluria.

My family uses this product for Pyroluria supplementation:


Here are some links to learn more about Pyroluria:

The Better Health Guy

Intregrative Psychiatry

Dr. Kaslow

Dr. Jockers

Primal Body Primal Mind



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